Article
mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.
Scientific reports - 12 Oct 2016
Manzoni Claudia, Mamais Adamantios, Roosen Dorien A, Dihanich Sybille, Soutar Marc P M, Plun-Favreau Helene, Bandopadhyay Rina, Hardy John, Tooze Sharon A, Cookson Mark R, Lewis Patrick A
Abstract excerpt
Leucine rich repeat kinase 2 is a complex enzyme with both kinase and GTPase activities, closely linked to the pathogenesis of several human disorders including Parkinson's disease, Crohn's disease, leprosy and cancer. LRRK2 has been implicated in numerous cellular processes; however its physiological function remains unclear. Recent reports suggest that LRRK2 can act to regulate the cellular catabolic process of...
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