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Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases

5 Sept 2012

Abstract excerpt

Macroautophagy is an important process for removing misfolded and aggregated protein in cells, the dysfunction of which has been directly linked to an increasing number of neurodegenerative disorders. However, the details of macroautophagy in prion diseases remain obscure. Here we demonstrated that in the terminal stages of scrapie strain 263K-infected hamsters and human genetic prion diseases, the...

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PMID: 22874564
DOI: 10.4161/auto.21482

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