Article
Planar cell polarity gene mutations contribute to the etiology of human neural tube defects in our population.
Birth defects research. Part A, Clinical and molecular teratology - 1 Aug 2014
De Marco Patrizia, Merello Elisa, Piatelli Gianluca, Cama Armando, Kibar Zoha, Capra Valeria
Abstract excerpt
Neural Tube Defects (NTDs) are congenital malformations that involve failure of the neural tube closure during the early phases of development at any level of the rostro-caudal axis. The planar cell polarity (PCP) pathway is a highly conserved, noncanonical Wnt-Frizzled-Dishevelled signaling cascade, that was first identified in the fruit fly Drosophila. We are here reviewing the role of the PCP pathway genes in...
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