Molecular structure of frizzled, a Drosophila tissue polarity gene.

doi:10.1093/genetics/126.2.401

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Article

Molecular structure of frizzled, a Drosophila tissue polarity gene.

Genetics - 1 Oct 1990

Adler P N, Vinson C, Park W J, Conover S, Klein L

Abstract excerpt

The function of the frizzled (fz) locus is required to coordinate the cytoskeletons of pupal epidermal cells so that a parallel array of cuticular hairs and bristles is produced. We report here the molecular cloning and characterization of the fz locus. The locus is very large. Mutations that inactivate the gene are spread over 100 kb of genomic DNA. The major mRNA product of the gene is a 4-kb RNA that is...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Chromosome Mapping
Cloning, Molecular
DNA Transposable Elements
Drosophila Proteins
Drosophila melanogaster
Female
Frizzled Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes

Insect Hormones

Male

Membrane Proteins

Molecular Sequence Data

Mutation

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 2174014
DOI: 10.1093/genetics/126.2.401
PMCID: PMC1204194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2174014-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Molecular structure of frizzled, a Drosophila tissue polarity gene.PMID 2174014Read ↗

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