Article
LARVA: an integrative framework for large-scale analysis of recurrent variants in noncoding annotations.
Nucleic acids research - 30 Sept 2015
Lochovsky Lucas, Zhang Jing, Fu Yao, Khurana Ekta, Gerstein Mark
Abstract excerpt
In cancer research, background models for mutation rates have been extensively calibrated in coding regions, leading to the identification of many driver genes, recurrently mutated more than expected. Noncoding regions are also associated with disease; however, background models for them have not...
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