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Article

BAY61-3606 potentiates the anti-tumor effects of TRAIL against colon cancer through up-regulating DR4 and down-regulating NF-κB.

Cancer letters - 28 Dec 2016

Du Jipei, Wang Yufang, Chen Degao, Ji Guangyu, Ma Qizhao, Liao Shiping, Zheng Yanjiang, Zhang Ji, Hou Yiping

Abstract excerpt

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is well known for its ability to preferentially induce apoptosis in malignant cells without causing damage to most normal cells. However, inherent and acquired resistance of tumor to TRAIL-induced apoptosis limits its therapeutic applicability. Here we show that the orally available tyrosine kinase inhibitor, BAY61-3606, enhances the sensitivity of...

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Source

Identifiers

PMID: 27721019
DOI: 10.1016/j.canlet.2016.10.002

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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