Article
Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells.
Blood - 15 Oct 2004
Leen Ann M, Sili Uluhan, Vanin Elio F, Jewell Alan M, Xie Weidong, Vignali Dario, Piedra Pedro A, Brenner Malcolm K, Rooney Cliona M
Abstract excerpt
Adenoviruses often cause lethal infections in immunocompromised individuals. Adoptive transfer of immune T cells offers a therapeutic option, but this strategy has been hindered by the paucity of information on molecular targets of cellular immunity and by the immunologic heterogeneity of the 51 human adenoviruses, which are grouped from A to F on the basis of genome size, composition, homology, and organization....
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