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Article

Identification of Sites in Adenovirus Hexon for Foreign Peptide Incorporation

24 Feb 2005

Abstract excerpt

Adenovirus type 5 (Ad5) is one of the most promising vectors for gene therapy applications. Genetic engineering of Ad5 capsid proteins has been employed to redirect vector tropism, to enhance infectivity, or to circumvent preexisting host immunity. As the most abundant capsid protein, hexon modification is particularly attractive. However, genetic modification of hexon often results in failure of rescuing viable...

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PMID: 15731232
DOI: 10.1128/jvi.79.6.3382-3390.2005

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