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The CD4+ T-cell response to adenovirus is focused against conserved residues within the hexon protein

13 Aug 2007

Abstract excerpt

Adenovirus is a significant pathogen in immunocompromised patients and is widely utilized as a gene delivery vector, so a detailed understanding of the human immune response to adenovirus infection is critical. This study characterized the adenovirus-specific CD4(+) T-cell response of healthy donors by incubation with whole virus or with individual hexon and fiber proteins. Adenovirus-specific CD4(+) T cells...

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PMID: 17698650
DOI: 10.1099/vir.0.82867-0

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