Article
Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish.
Blood cancer journal - 7 Oct 2016
Lim K-H, Chang Y-C, Chiang Y-H, Lin H-C, Chang C-Y, Lin C-S, Huang L, Wang W-T, Gon-Shen Chen C, Chou W-C, Kuo Y-Y
Abstract excerpt
CALR mutations are identified in about 30% of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs) including essential thrombocythemia (ET) and primary myelofibrosis. Although the molecular pathogenesis of CALR mutations leading to MPNs has been studied using in vitro cell lines models, how mutant CALR may affect developmental hematopoiesis remains unknown. Here we took advantage of the zebrafish model to...
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