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Article

HNF4α and CDH1 are associated with ulcerative colitis in a Dutch cohort.

Inflammatory bowel diseases - 1 Aug 2011

van Sommeren Suzanne, Visschedijk Marijn C, Festen Eleonora A M, de Jong Dirk J, Ponsioen Cyriel Y, Wijmenga Cisca, Weersma Rinse K

Abstract excerpt

BACKGROUND: Inflammatory bowel diseases (IBDs), consisting of ulcerative colitis (UC) and Crohn's disease (CD), are complex disorders with multiple genes contributing to disease pathogenesis. A recent genome-wide association scan identified three novel susceptibility loci for UC: HNF4α, CDH1, and LAMB1. We performed an analysis of these three loci in an independent cohort. METHODS: In all, 821 UC patients and...

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Source

Identifiers

PMID: 21744425
DOI: 10.1002/ibd.21541

Genes

CDH1
LAMB1

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