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Article

Genetic Variation in the 11β-hydroxysteroid-dehydrogenase 1 Gene Determines NAFLD and Visceral Obesity.

The Journal of clinical endocrinology and metabolism - 1 Dec 2016

Lutz Stefan Z, Peter Andreas, Machicao Fausto, Lamprinou Apostolia, Machann Jürgen, Schick Fritz, Königsrainer Ingmar, Königsrainer Alfred, Fritsche Andreas, Staiger Harald, Häring Hans-Ulrich, Stefan Norbert, Kantartzis Konstantinos

Abstract excerpt

CONTEXT/OBJECTIVE: Acute pharmacological inhibition of 11β-hydroxysteroid-dehydrogenase 1 (11β-HSD1), which converts cortisone into the much more potent cortisol in peripheral tissues, results in reduction of total, visceral, and liver fat but not insulin resistance. We now investigated whether lifelong alterations of 11β-HSD1 activity similarly affect these cardiometabolic risk parameters by studying...

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Identifiers

PMID: 27715400
DOI: 10.1210/jc.2016-2498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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