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Article

Effect of Cellular Senescence on the Growth of HER2-Positive Breast Cancers

13 May 2015

Abstract excerpt

BACKGROUND: Oncogene-induced senescence (OIS) is a tumor suppressor mechanism. However, senescent cells remain viable and display a distinct secretome (also known as senescence-associated secretory phenotype [SASP] or senescence messaging secretome, [SMS]) that, paradoxically, includes protumorigenic factors. OIS can be triggered by ectopic overexpression of HER2, a receptor tyrosine kinase and the driving...

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PMID: 25972601
DOI: 10.1093/jnci/djv020

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