Article
Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).
Journal of translational medicine - 27 Jan 2015
Freeman Christine M, Crudgington Sean, Stolberg Valerie R, Brown Jeanette P, Sonstein Joanne, Alexis Neil E, Doerschuk Claire M, Basta Patricia V, Carretta Elizabeth E, Couper David J, Hastie Annette T, Kaner Robert J, O'Neal Wanda K, Paine Robert, Rennard Stephen I, Shimbo Daichi, Woodruff Prescott G, Zeidler Michelle, Curtis Jeffrey L
Abstract excerpt
BACKGROUND: Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multi-center longitudinal, observational study to identify novel phenotypes and biomarkers of chronic obstructive pulmonary disease (COPD). In a subset of 300 subjects enrolled at six clinical centers, we are performing flow cytometric analyses of leukocytes from induced sputum, bronchoalveolar lavage (BAL) and peripheral blood....
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