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Article

ABCC3 and GSTM5 gene polymorphisms affect overall survival in Polish acute myeloid leukaemia patients.

Current problems in cancer - 1 Oct 2021

Butrym Aleksandra, Łacina Piotr, Bogunia-Kubik Katarzyna, Mazur Grzegorz

Abstract excerpt

Acute myeloid leukaemia (AML) is a very heterogeneous malignancy in which standard treatment is based on chemotherapy. Resistance to chemotherapeutic agents remains a big problem in AML, because negatively influences patient overall survival. Several resistance mechanisms have been described, the best of which is the process of drug removal from the cell and/or nucleus by membrane transport proteins. The aim of...

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PMID: 33714589
DOI: 10.1016/j.currproblcancer.2021.100729

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