Article
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.
Nature communications - 4 Oct 2016
Huang Tianzhi, Alvarez Angel A, Pangeni Rajendra P, Horbinski Craig M, Lu Songjian, Kim Sung-Hak, James C David, J Raizer Jeffery, A Kessler John, Brenann Cameron W, Sulman Erik P, Finocchiaro Gaetano, Tan Ming, Nishikawa Ryo, Lu Xinghua, Nakano Ichiro, Hu Bo, Cheng Shi-Yuan
Abstract excerpt
Molecularly defined subclassification is associated with phenotypic malignancy of glioblastoma (GBM). However, current understanding of the molecular basis of subclass conversion that is often involved in GBM recurrence remain rudimentary at best. Here we report that canonical Wnt signalling that is active in proneural (PN) but inactive in mesenchymal (MES) GBM, along with miR-125b and miR-20b that are expressed...
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