Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wnt5a Drives an Invasive Phenotype in Human Glioblastoma Stem-like Cells.

Cancer research - 15 Feb 2017

Binda Elena, Visioli Alberto, Giani Fabrizio, Trivieri Nadia, Palumbo Orazio, Restelli Silvia, Dezi Fabio, Mazza Tommaso, Fusilli Caterina, Legnani Federico, Carella Massimo, Di Meco Francesco, Duggal Rohit, Vescovi Angelo L

Abstract excerpt

Brain invasion by glioblastoma determines prognosis, recurrence, and lethality in patients, but no master factor coordinating the invasive properties of glioblastoma has been identified. Here we report evidence favoring such a role for the noncanonical WNT family member Wnt5a. We found the most invasive gliomas to be characterized by Wnt5a overexpression, which correlated with poor prognosis and also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Invasiveness

Share to Neoplastic Stem Cells

Share to Phenotype

Share to Wnt-5a Protein

Source

Identifiers

PMID: 28011620
DOI: 10.1158/0008-5472.CAN-16-1693

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wnt5a Drives an Invasive Phenotype in Human Glioblastoma Stem-like Cells.PMID 28011620Read ↗

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive GrowthSemantic proximity Read ↗

Glioblastoma cells increase expression of notch signaling and synaptic genes within infiltrated brain tissueSemantic proximity Read ↗

Glioblastoma CD105+ cells define a SOX2− cancer stem cell-like subpopulation in the pre-invasive nicheSemantic proximity Read ↗

S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in GlioblastomaSemantic proximity Read ↗

Cancer stem cell contribution to glioblastoma invasivenessSemantic proximity Read ↗

A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor MicroenvironmentSemantic proximity Read ↗

Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcomeSemantic proximity Read ↗

Primary Glioblastomas Express Mesenchymal Stem-Like PropertiesSemantic proximity Read ↗

Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltrationSemantic proximity Read ↗

The landscape of the mesenchymal signature in brain tumoursSemantic proximity Read ↗

CD95 maintains stem cell-like and non-classical EMT programs in primary human glioblastoma cellsSemantic proximity Read ↗

Genomics and Prognosis Analysis of Epithelial-Mesenchymal Transition in GliomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.