Article
Dehomocysteinylation is catalysed by the sirtuin-2-like bacterial lysine deacetylase CobB.
The FEBS journal - 1 Nov 2016
Mei Xin-Yu, He Xia-Di, Huang Lei, Qi Da-Shi, Nie Ji, Li Yang, Si Wen, Zhao Shi-Min
Abstract excerpt
Hyperhomocysteinemia, which is characterized by elevated blood levels of the non-protein amino acid homocysteine (Hcy), is an independent risk factor for many diseases, including cardiovascular diseases, neurodegenerative diseases and birth defects. The incorporation of homocysteine into proteins, known as protein N-homocysteinylation, has been considered a major mechanism that contributes to...
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