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Article

Characterization of CobB kinetics and inhibition by nicotinamide.

PloS one - 1 Jan 2017

Gallego-Jara Julia, Écija Conesa Ana, de Diego Puente Teresa, Lozano Terol Gema, Cánovas Díaz Manuel

Abstract excerpt

Lysine acetylation has emerged as a global protein regulation system in all domains of life. Sirtuins, or Sir2-like enzymes, are a family of histone deacetylases characterized by their employing NAD+ as a co-substrate. Sirtuins can deacetylate several acetylated proteins, but a consensus substrate recognition sequence has not yet been established. Product inhibition of many eukaryotic sirtuins by nicotinamide and...

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Identifiers

PMID: 29253849
DOI: 10.1371/journal.pone.0189689
PMCID: PMC5734772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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