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Article

Association of Polymorphisms in the Interleukin 6 Receptor Complex with Obesity and Hyperandrogenism

1 Aug 2003

Abstract excerpt

OBJECTIVE: Interleukin-6 (IL-6), is an inflammatory cytokine that may influence the pathogenesis of obesity and hyperandrogenism. IL-6 exerts its actions through a heterodimeric receptor consisting of two membrane-bound glycoproteins: an 80-kDa IL-6 binding unit (IL6R-alpha) and a 130-kDa IL-6 signal transducer (gp130). Genetic variability at these loci might contribute to explain the development of obesity and...

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Adipokines, Inflammation, and Metabolic Diseases
Ovarian function and disorders
Regulation of Appetite and Obesity

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12917504
DOI: 10.1038/oby.2003.136

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