Article
Genome-wide association analysis identifies genetic loci associated with resistance to multiple antimalarials in Plasmodium falciparum from China-Myanmar border.
Scientific reports - 3 Oct 2016
Wang Zenglei, Cabrera Mynthia, Yang Jingyun, Yuan Lili, Gupta Bhavna, Liang Xiaoying, Kemirembe Karen, Shrestha Sony, Brashear Awtum, Li Xiaolian, Porcella Stephen F, Miao Jun, Yang Zhaoqing, Su Xin-Zhuan, Cui Liwang
Abstract excerpt
Drug resistance has emerged as one of the greatest challenges facing malaria control. The recent emergence of resistance to artemisinin (ART) and its partner drugs in ART-based combination therapies (ACT) is threatening the efficacy of this front-line regimen for treating Plasmodium falciparum parasites. Thus, an understanding of the molecular mechanisms that underlie the resistance to ART and the partner drugs...
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