Article
A novel assay to detect calreticulin mutations in myeloproliferative neoplasms.
Oncotarget - 24 Jan 2017
Rosso Valentina, Petiti Jessica, Bracco Enrico, Pedrola Roberto, Carnuccio Francesca, Signorino Elisabetta, Carturan Sonia, Calabrese Chiara, Bot-Sartor Giada, Ronconi Michela, Serra Anna, Saglio Giuseppe, Frassoni Francesco, Cilloni Daniela
Abstract excerpt
The myeloproliferative neoplasms are chronic myeloid cancers divided in Philadelphia positive (Ph+), chronic myeloid leukemia, or negative: polycythemia vera (PV) essential thrombocythemia (ET), and primary myelofibrosis (PMF). Most Ph negative cases have an activating JAK2 or MPL mutation. Recently, somatic mutations in the calreticulin gene (CALR) were detected in 56-88% of JAK2/MPL-negative patients affected...
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