Article
Proinflammatory signals are insufficient to drive definitive hematopoietic specification of human HSCs in vitro.
Experimental hematology - 1 Jan 2017
Giorgetti Alessandra, Castaño Julio, Bueno Clara, Díaz de la Guardia Rafael, Delgado Mario, Bigas Anna, Espinosa Lluis, Menendez Pablo
Abstract excerpt
Recent studies in zebrafish and mice have revealed that proinflammatory signaling is a positive regulator of definitive hematopoietic development. Whether proinflammatory signaling also regulates human hematopoietic specification remains unknown. Here, we explored the impact of the proinflammatory cytokines tumor necrosis factor-α (TNFα), interferon-γ (IFNγ), and interleukin-1β (IL1β) on in vitro hematopoietic...
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