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Protocol for the generation of HLF+ HOXA+ human hematopoietic progenitor cells from pluripotent stem cells

24 Jan 2025

Abstract excerpt

Hematopoietic stem cells (HSCs) generate blood and immune cells. Here, we present a protocol to differentiate human pluripotent stem cells (hPSCs) into hematopoietic progenitors that express the signature HSC transcription factors HLF , HOXA5 , HOXA7 , HOXA9 , and HOXA10. hPSCs are dissociated, seeded, and then sequentially differentiated into posterior primitive streak, lateral mesoderm, artery endothelium,...

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PMID: 39864063
DOI: 10.1016/j.xpro.2024.103592

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