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Article

Retinoic acid regulates hematopoietic development from human pluripotent stem cells.

Stem cell reports - 10 Feb 2015

Rönn Roger E, Guibentif Carolina, Moraghebi Roksana, Chaves Patricia, Saxena Shobhit, Garcia Bradley, Woods Niels-Bjarne

Abstract excerpt

The functions of retinoic acid (RA), a potent morphogen with crucial roles in embryogenesis including developmental hematopoiesis, have not been thoroughly investigated in the human setting. Using an in vitro model of human hematopoietic development, we evaluated the effects of RA signaling on the development of blood and on generated hematopoietic progenitors. Decreased RA signaling increases the generation of...

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Identifiers

PMID: 25680478
DOI: 10.1016/j.stemcr.2015.01.009
PMCID: PMC4325193

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