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Three-dimensional structure of a flavivirus dumbbell RNA reveals molecular details of an RNA regulator of replication

17 May 2021

Abstract excerpt

Mosquito-borne flaviviruses (MBFVs) including dengue, West Nile, yellow fever, and Zika viruses have an RNA genome encoding one open reading frame flanked by 5' and 3' untranslated regions (UTRs). The 3' UTRs of MBFVs contain regions of high sequence conservation in structured RNA elements known as dumbbells (DBs). DBs regulate translation and replication of the viral RNA genome, functions proposed to depend on...

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PMID: 34133732
DOI: 10.1093/nar/gkab462

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