Article
N-linked glycosylation sites determine HERG channel surface membrane expression.
The Journal of physiology - 15 Feb 1999
Petrecca K, Atanasiu R, Akhavan A, Shrier A
Abstract excerpt
1. Long QT syndrome (LQT) is an electrophysiological disorder that can lead to sudden death from cardiac arrhythmias. One form of LQT has been attributed to mutations in the human ether-a-go-go-related gene (HERG) that encodes a voltage-gated cardiac K+ channel. While a recent report indicates th...
Topics
- Anti-Bacterial Agents
- Blotting, Western
- Cation Transport Proteins
- Cell Line
- DNA-Binding Proteins
- ERG1 Potassium Channel
- Ether-A-Go-Go Potassium Channels
- Glycosylation
- Green Fluorescent Proteins
- Humans
- Intracellular Membranes
- Ion Channel Gating
- Kidney
- Luminescent Proteins
- Membrane Potentials
- Microscopy, Confocal
- Mutation
- Patch-Clamp Techniques