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Article

N-linked glycosylation sites determine HERG channel surface membrane expression.

The Journal of physiology - 15 Feb 1999

Petrecca K, Atanasiu R, Akhavan A, Shrier A

Abstract excerpt

1. Long QT syndrome (LQT) is an electrophysiological disorder that can lead to sudden death from cardiac arrhythmias. One form of LQT has been attributed to mutations in the human ether-a-go-go-related gene (HERG) that encodes a voltage-gated cardiac K+ channel. While a recent report indicates that LQT in some patients is associated with a mutation of HERG at a consensus extracellular N-linked glycosylation site...

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Identifiers

PMID: 9925876
DOI: 10.1111/j.1469-7793.1999.041ad.x
PMCID: PMC2269130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

N-linked glycosylation sites determine HERG channel surface membrane expression.PMID 9925876Read ↗

Effects of N-glycosylation on hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.Semantic proximity Read ↗

Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG ChannelsSemantic proximity Read ↗

Trafficking-deficient hERG K⁺ channels linked to long QT syndrome are regulated by a microtubule-dependent quality control compartment in the ER.Semantic proximity Read ↗

Functional studies on three novel HCNH2 mutations in Taiwan: identification of distinct mechanisms of channel defect and dissociation between glycosylation defect and assembly defect.Semantic proximity Read ↗

Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à-go-go-Related Gene.Semantic proximity Read ↗

Defective protein trafficking in hERG-associated hereditary long QT syndrome (LQT2): molecular mechanisms and restoration of intracellular protein processing.Semantic proximity Read ↗

Identification and functional characterization of the human ether-a-go-go-related gene Q738X mutant associated with hereditary long QT syndrome type 2.Semantic proximity Read ↗

Identification of a COOH-terminal segment involved in maturation and stability of human ether-a-go-go-related gene potassium channels.Semantic proximity Read ↗

Physiologic and pathophysiologic consequences of altered sialylation and glycosylation on ion channel function.Semantic proximity Read ↗

The glycosylation of the extracellular loop of β2 subunits diversifies functional phenotypes of BK Channels.Semantic proximity Read ↗

Pharmacological rescue of hERG currents carried out by G604S and wide type hERG co-expression.Semantic proximity Read ↗

O-glycosylation of the cardiac I(Ks) complex.Semantic proximity Read ↗

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