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The Correlation of Mouse Double Minute 4 (MDM4) Polymorphisms (rs4245739, rs1563828, rs11801299, rs10900598, and rs1380576) with Cancer Susceptibility: A Meta-Analysis.

Medical science monitor : international medical journal of experimental and clinical research - 29 Mar 2022

Chen Jian, Li Xudong, Liu Ruihao, Xie Yufen, Liu Zhigao, Xiong Haiwei, Li Yingliang

Abstract excerpt

BACKGROUND Mouse double minute 4 (MDM4) has been extensively investigated as a negative regulator of P53, its negative feedback loop, and the effect of its genetic polymorphisms on cancers. However, many studies showed varying and even conflicting results. Therefore, we employed meta-analysis to further assess the intensity of the connection between MDM4 polymorphisms and malignancies. MATERIAL AND METHODS We...

Topics

Animals
Cell Cycle Proteins
Esophageal Neoplasms
Esophageal Squamous Cell Carcinoma
Genetic Predisposition to Disease
Humans
Mice
Nuclear Proteins
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins

Risk Factors

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Identifiers

PMID: 35347102
DOI: 10.12659/MSM.935671
PMCID: PMC8976448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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