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miRNA-558 promotes gastric cancer progression through attenuating Smad4-mediated repression of heparanase expression

29 Sept 2016

Abstract excerpt

Previous studies have indicated that as the only mammalian endo-β-D-glucuronidase, heparanase (HPSE) is up-regulated and associated with poor prognosis in gastric cancer, while the underlying mechanisms still remain to be determined. Herein, through integrative analysis of public datasets, we found microRNA-558 (miR-558) and SMAD family member 4 (Smad4) as the crucial transcription regulators of HPSE expression...

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PMID: 27685626
DOI: 10.1038/cddis.2016.293

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