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Article

Repression of p63 and induction of EMT by mutant Ras in mammary epithelial cells.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2016

Yoh Kathryn E, Regunath Kausik, Guzman Asja, Lee Seung-Min, Pfister Neil T, Akanni Olutosin, Kaufman Laura J, Prives Carol, Prywes Ron

Abstract excerpt

The p53-related transcription factor p63 is required for maintenance of epithelial cell differentiation. We found that activated forms of the Harvey Rat Sarcoma Virus GTPase (H-RAS) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) oncogenes strongly repress expression of ∆Np63α, the predominant p63 isoform in basal mammary epithelial cells. This regulation occurs at the...

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Identifiers

PMID: 27681615
DOI: 10.1073/pnas.1613417113
PMCID: PMC5068336

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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