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Article

Two-phase SSU and SKAT in genetic association studies.

Journal of genetics - 1 Jan 2020

Xue Yuan, Ding Juan, Wang Jinjuan, Zhang Sanguo, Pan Dongdong

Abstract excerpt

The sum of squared score (SSU) and sequence kernel association test (SKAT) are the two good alternative tests for genetic association studies in case-control data. Both SSU and SKAT are derived through assuming a dose-response model between the risk of disease and genotypes. However, in practice, the real genetic mode of inheritance is impossible to know. Thus, these two tests might losepower substantially as...

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PMID: 32089528

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