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Article

A unified method for detecting secondary trait associations with rare variants: application to sequence data.

PLoS genetics - 1 Jan 2012

Liu Dajiang J, Leal Suzanne M

Abstract excerpt

Next-generation sequencing has made possible the detection of rare variant (RV) associations with quantitative traits (QT). Due to high sequencing cost, many studies can only sequence a modest number of selected samples with extreme QT. Therefore association testing in individual studies can be underpowered. Besides the primary trait, many clinically important secondary traits are often measured. It is highly...

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Identifiers

PMID: 23166519
DOI: 10.1371/journal.pgen.1003075
PMCID: PMC3499373

Genes

LDLR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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