Article
FGF4 induces epithelial-mesenchymal transition by inducing store-operated calcium entry in lung adenocarcinoma.
Oncotarget - 8 Nov 2016
Qi Lisha, Song Wangzhao, Li Lingmei, Cao Lu, Yu Yue, Song Chunmin, Wang Yalei, Zhang Fei, Li Yang, Zhang Bin, Cao Wenfeng
Abstract excerpt
Several fibroblast growth factor (FGF) isoforms act to stimulate epithelial-mesenchymal transition (EMT) during cancer progression. FGF4 and FGF7 are two ligands of FGF receptor 2 (FGFR2). Using two lung adenocarcinoma (ADC) cell lines, A549 and H1299, we showed that FGF4, but not FGF7, altered cell morphology, promoted EMT-associated protein expression, and enhanced cell proliferation, migration/invasion and...
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