Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Context-dependent dysregulation of store-operated calcium channels in head and neck squamous cell carcinoma.

PloS one - 1 Jan 2026

Ghozlan Heba, Al-Malahmeh Saja, Al-Shboul Othman, Mistareehi Anas J, Elsalem Lina

Abstract excerpt

Store-operated calcium entry (SOCE), mediated by ORAI1-3 calcium channels and stromal interaction molecules STIM1 and STIM2, is increasingly recognized as a regulator of cancer progression. However, its role in head and neck squamous cell carcinoma (HNSCC) and its relationship with major oncogenic pathways remain poorly defined. Transcriptomic and clinical data from The Cancer Genome Atlas (TCGA) were analyzed to...

Topics

Join the communities discussing this publication.

Boron Compounds
Calcium
Calcium Channels
Class I Phosphatidylinositol 3-Kinases
Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Squamous Cell Carcinoma of Head and Neck

Stromal Interaction Molecule 1

Source

Open in PubMed Open full text

Identifiers

PMID: 41801973
DOI: 10.1371/journal.pone.0344393
PMCID: PMC12970912

Genes

STIM1
ORAI1
PIK3CA
EGFR
STIM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Context-dependent dysregulation of store-operated calcium channels in head and neck squamous cell carcinoma.PMID 41801973Read ↗

STIM and ORAI proteins: crucial roles in hallmarks of cancerSemantic proximity Read ↗

Understanding Stim-1 Regulatory Networks in Nasopharyngeal Cancer Using Functional, Transcriptomics, Proteomics, and in-silico ApproachesSemantic proximity Read ↗

Targeting Stim and Orai Proteins as an Alternative Approach in Anticancer TherapySemantic proximity Read ↗

The effects of Stim1 and Orai1 expression levels on lymph node metastases and prognosis in patients with triple negative breast cancerSemantic proximity Read ↗

Evaluation for the Genetic Association between Store-Operated Calcium Influx Pathway (STIM1 and ORAI1) and Human Hepatocellular Carcinoma in Patients with Chronic Hepatitis B InfectionSemantic proximity Read ↗

Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer CellsSemantic proximity Read ↗

<i>TAS2R10</i> Suppresses ABCG2 Transporter-Associated Chemoresistance and Enhances Cisplatin Sensitivity in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

CRAC channels, calcium, and cancer in light of the driver and passenger concept.Semantic proximity Read ↗

Store-operated calcium entry dysfunction in CRAC channelopathy: Insights from a novel STIM1 mutation.Semantic proximity Read ↗

Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma.Semantic proximity Read ↗

Orai3 Regulates Pancreatic Cancer Metastasis by Encoding a Functional Store Operated Calcium Entry ChannelSemantic proximity Read ↗

STIM1 GoF Mutants: Genotype-Phenotype Relationships Across the Stormorken/TAM/YPS Spectrum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.