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Article

Targeted next-generation sequencing of CIC-DUX4 soft tissue sarcomas demonstrates low mutational burden and recurrent chromosome 1p loss.

Human pathology - 1 Dec 2016

Lazo de la Vega Lorena, Hovelson Daniel H, Cani Andi K, Liu Chia-Jen, McHugh Jonathan B, Lucas David R, Thomas Dafydd G, Patel Rajiv M, Tomlins Scott A

Abstract excerpt

Gene fusions between CIC and DUX4 define a rare class of soft tissue sarcomas poorly understood at the molecular level. Previous karyotyping and fluorescence in situ hybridization studies support chromosome 8 trisomy as a recurrent alteration; however, other driving alterations are largely unknown. Thus, we analyzed 11 formalin-fixed, paraffin-embedded CIC-DUX4 sarcoma tissue samples (including 3 sample pairs)...

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Topics

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Share to Chromosome Deletion
Share to Chromosomes, Human, Pair 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Multiplex Polymerase Chain Reaction

Share to Oncogene Proteins, Fusion

Share to Predictive Value of Tests

Share to Sarcoma

Share to Soft Tissue Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 27664537
DOI: 10.1016/j.humpath.2016.09.004
PMCID: PMC5125884

Genes

CIC
DUX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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