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Article

DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumors: a potential association with androgenic effects.

Human pathology - 1 Jan 2017

Kato Noriko, Kusumi Tomomi, Kamataki Akihisa, Tsunoda Rikiya, Fukase Masayuki, Kurose Akira

Abstract excerpt

Sertoli-Leydig cell tumors (SLCTs) are representative of androgenic ovarian tumors, and they show diverse histologic differentiation, including heterologous differentiation. Genetically, SLCTs are characterized by the presence of DICER1 mutations. In the present study, we analyzed the correlation between somatic DICER1 hotspot mutations and clinicopathological features in 10 ovarian SLCTs. Six of the 10 (60%)...

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Identifiers

PMID: 27664536
DOI: 10.1016/j.humpath.2016.09.005

Genes

DICER1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DICER1 hotspot mutations in ovarian Sertoli-Leydig cell tumors: a potential association with androgenic effects.PMID 27664536Read ↗

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