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Article

Age and DRD4 Genotype Moderate Associations Between Stimulant Treatment History and Cortex Structure in Attention-Deficit/Hyperactivity Disorder.

Journal of the American Academy of Child and Adolescent Psychiatry - 1 Oct 2016

Schweren Lizanne J S, Hartman Catharina A, Heslenfeld Dirk J, Groenman Annabeth P, Franke Barbara, Oosterlaan Jaap, Buitelaar Jan K, Hoekstra Pieter J

Abstract excerpt

OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) has been associated with dopaminergic imbalance and subtle volume decreases in the brain. Stimulants acutely enhance dopaminergic neurotransmission. Long-term effects of prolonged manipulation of the dopaminergic system on brain structure remain poorly understood; they could be beneficial or unfavorable and could be moderated by common genetic variants...

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Source

Identifiers

PMID: 27663943
DOI: 10.1016/j.jaac.2016.06.013

Genes

DRD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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