Article
Enlarged striatal volume in adults with ADHD carrying the 9-6 haplotype of the dopamine transporter gene DAT1.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Aug 2016
Onnink A Marten H, Franke Barbara, van Hulzen Kimm, Zwiers Marcel P, Mostert Jeanette C, Schene Aart H, Heslenfeld Dirk J, Oosterlaan Jaap, Hoekstra Pieter J, Hartman Catharina A, Vasquez Alejandro Arias, Kan Cornelis C, Buitelaar Jan, Hoogman Martine
Abstract excerpt
The dopamine transporter gene, DAT1 (SLC6A3), has been studied extensively as a candidate gene for attention-deficit/hyperactivity disorder (ADHD). Different alleles of variable number of tandem repeats (VNTRs) in this gene have been associated with childhood ADHD (10/10 genotype and haplotype 10-6) and adult ADHD (haplotype 9-6). This suggests a differential association depending on age, and a role of DAT1 in...
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