Article
The dopamine receptor D4 7-repeat allele influences neurocognitive functioning, but this effect is moderated by age and ADHD status: an exploratory study.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Apr 2012
Altink Marieke E, Rommelse Nanda N J, Slaats-Willemse Dorine I E, Vásquez Alejandro Arias, Franke Barbara, Buschgens Cathelijne J M, Fliers Ellen A, Faraone Stephen V, Sergeant Joseph A, Oosterlaan Jaap, Buitelaar Jan K
Abstract excerpt
OBJECTIVES: Evidence suggests the involvement of the dopamine D4 receptor gene (DRD4) in the pathogenesis of ADHD, but the exact mechanism is not well understood. Earlier reports on the effects of DRD4 polymorphisms on neurocognitive and neuroimaging measures are inconsistent. This study investigated the functional consequences of the 7-repeat allele of DRD4 on neurocognitive endophenotypes of ADHD in the Dutch...
Topics
- Adolescent
- Age Factors
- Attention Deficit Disorder with Hyperactivity
- Case-Control Studies
- Child
- Child, Preschool
- Cognition
- Female
- Gene Frequency