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Article

Amino acid substitutions occurring during adaptation of an emergent H5N6 avian influenza virus to mammals.

Archives of virology - 1 Jun 2016

Peng Xiuming, Wu Haibo, Peng Xiaorong, Wu Xiaoxin, Cheng Linfang, Liu Fumin, Ji Shujing, Wu Nanping

Abstract excerpt

Avian influenza viruses (AIVs) are known to cross species barriers, and emergent highly pathogenic H5N6 AIVs pose a serious threat to human health and the poultry industry. Here, we serially passaged an H5N6 virus 10 times in BALB/c mice. The pathogenicity of the wild-type 6D2 (WT-6D2) and mammal-adapted 6D2 strain (MA-6D2) were compared. The viral titer in multiple organs and the death rate for MA-6D2 were...

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PMID: 26997612
DOI: 10.1007/s00705-016-2826-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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