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Article

Midline crossing and Slit responsiveness of commissural axons require USP33.

Nature neuroscience - 1 Sept 2009

Yuasa-Kawada Junichi, Kinoshita-Kawada Mariko, Wu Guan, Rao Yi, Wu Jane Y

Abstract excerpt

Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance...

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Identifiers

PMID: 19684588
DOI: 10.1038/nn.2382
PMCID: PMC3893063

Genes

USP33

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Related research

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Research trail→

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Midline crossing and Slit responsiveness of commissural axons require USP33.PMID 19684588Read ↗

Crossing the midline: roles and regulation of Robo receptors.Semantic proximity Read ↗

Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline.Semantic proximity Read ↗

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Dscam1 Forms a Complex with Robo1 and the N-Terminal Fragment of Slit to Promote the Growth of Longitudinal Axons.Semantic proximity Read ↗

Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.Semantic proximity Read ↗

The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.Semantic proximity Read ↗

Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion.Semantic proximity Read ↗

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Slit-Robo signalling prevents sensory cells from crossing the midline in Drosophila.Semantic proximity Read ↗

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In Vivo Functional Analysis of Drosophila Robo1 Fibronectin Type-III Repeats.Semantic proximity Read ↗

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