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Article

In Vivo Costimulation Blockade-Induced Regulatory T Cells Demonstrate Dominant and Specific Tolerance to Porcine Islet Xenografts.

Transplantation - 1 Jul 2017

Wu Jingjing, Hu Min, Qian Yi Wen, Hawthorne Wayne J, Burns Heather, Liuwantara David, Alexander Stephen I, Yi Shounan, O'Connell Philip J

Abstract excerpt

BACKGROUND: Although islet xenotransplantation is a promising therapy for type 1 diabetes, its clinical application has been hampered by cellular rejection and the requirement for high levels of immunosuppression. The aim of this study was to determine the role of Foxp3 regulatory T (Treg) cells in costimulation blockade-induced dominant tolerance to porcine neonatal islet cell cluster (NICC) xenografts in mice....

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Source

Identifiers

PMID: 27653300
DOI: 10.1097/TP.0000000000001482

Genes

CTLA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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