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Xenografted Islet Cell Clusters From <i>INS</i>LEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice

21 Apr 2012

Abstract excerpt

Islet transplantation is a potential treatment for type 1 diabetes, but the shortage of donor organs limits its routine application. As potential donor animals, we generated transgenic pigs expressing LEA29Y, a high-affinity variant of the T-cell costimulation inhibitor CTLA-4Ig, under the control of the porcine insulin gene promoter. Neonatal islet cell clusters (ICCs) from INSLEA29Y transgenic (LEA-tg) pigs and...

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PMID: 22522620
DOI: 10.2337/db11-1325

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