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Article

Ancestry-based stratified analysis of Immunochip data identifies novel associations with celiac disease.

European journal of human genetics : EJHG - 1 Dec 2016

Garcia-Etxebarria Koldo, Jauregi-Miguel Amaia, Romero-Garmendia Irati, Plaza-Izurieta Leticia, Legarda Maria, Irastorza Iñaki, Bilbao Jose Ramon

Abstract excerpt

To identify candidate genes in celiac disease (CD), we reanalyzed the whole Immunochip CD cohort using a different approach that clusters individuals based on immunoancestry prior to disease association analysis, rather than by geographical origin. We detected 636 new associated SNPs (P<7.02 × 10-07) and identified 5 novel genomic regions, extended 8 others previously identified and also detected 18 isolated...

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Identifiers

PMID: 27650971
DOI: 10.1038/ejhg.2016.120
PMCID: PMC5117923

Genes

CCNT2
REL
SORD

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