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Article

Intra- and extracellular plasminogen activator inhibitor-1 regulate effect of vitronectin against radiation-induced endothelial cell death.

Vascular pharmacology - 1 Dec 2016

Hazawa Masaharu, Yasuda Takeshi, Saotome-Nakamura Ai, Tomiyama Kenichi, Obara Chizuka, Goto Takaya, Tajima Katsushi

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1) is induced by radiation resulting in endothelial cell impairment, potentially leading to multiple organ failure. Vitronectin (VN) is a 75-kDa glycoprotein (VN75) cleaved into two forms (VN75 or VN65/10) by furin, which is regulated by intracellular PAI-1. VN protects against radiation-induced endothelial cell death, but the mechanisms involved in VN processing and its...

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Identifiers

PMID: 27650166
DOI: 10.1016/j.vph.2016.09.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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