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Antiangiogenic proteins require plasma fibronectin or vitronectin for <i>in vivo</i> activity

17 Sept 2003

Abstract excerpt

Fragmentation of various extracellular matrix and blood proteins generates antiangiogenic substances that are physiological regulators of angiogenesis. Some of these compounds are in clinical trials as inhibitors of tumor angiogenesis. Anastellin, an antiangiogenic protein fragment derived from fibronectin, was unable to inhibit matrigel plug angiogenesis in mice that lack plasma fibronectin. Anastellin was fully...

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PMID: 13679585
DOI: 10.1073/pnas.1635112100

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