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Article

Integrative structural analysis of the human LRP2-LRPAP1 complex reveals multiple regulatory sites.

Communications biology - 18 Apr 2026

Ramanadane Karthik, Di Ianni Alessio, Graziadei Andrea, Tosatto Laura, Miele Federica, Coscia Francesca

Abstract excerpt

The low-density lipoprotein receptor-related protein 2 (LRP2) is an endocytic receptor implicated in the homeostasis of multiple organs. While the low-density lipoprotein receptor-related protein-associated protein 1 (LRPAP1) interacts with LRP2, its regulatory role remains elusive. Past studies showed that a single LRPAP1 molecule binds to LRP2 via complement-type repeats. However, many domains of this kind...

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Identifiers

PMID: 41998130
DOI: 10.1038/s42003-026-09996-y
PMCID: PMC13463032

Genes

LRP2
LRPAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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