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Multi-Phenotypic subtyping of circulating tumor cells using sequential fluorescent quenching and restaining

20 Sept 2016

Abstract excerpt

In tissue biopsies formalin fixed paraffin embedded cancer blocks are micro-sectioned producing multiple semi-identical specimens which are analyzed and subtyped proteomically, and genomically, with numerous biomarkers. In blood based biopsies (BBBs), blood is purified for circulating tumor cells (CTCs) and clinical utility is typically limited to cell enumeration, as only 2-3 positive fluorescent markers and 1...

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PMID: 27647345
DOI: 10.1038/srep33488

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