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Antigen-agnostic microfluidics-based circulating tumor cell enrichment and downstream molecular characterization

23 Oct 2020

Abstract excerpt

Circulating tumor cells (CTC) isolated from the peripheral blood of cancer patients by a minimally invasive procedure provide surrogate markers of the tumor that can be repeatedly sampled. However, the selection and enumeration of CTCs by traditional methods based on surface proteins like EPCAM may not detect CTCs with a mesenchymal phenotype. Here, we employed an antibody-agnostic platform, the Parsortix® PR1...

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PMID: 33095819
DOI: 10.1371/journal.pone.0241123

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