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Cell size and cancer: a new solution to Peto's paradox?

14 Oct 2014

Abstract excerpt

Cancer, one of the leading health concerns for humans, is by no means a human-unique malady. Accumulating evidence shows that cancer kills domestic and wild animals at a similar rate to humans and can even pose a conservation threat to certain species. Assuming that each physiologically active and proliferating cell is at risk of malignant transformation, any evolutionary increase in the number of cells (and thus...

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PMID: 25667599
DOI: 10.1111/eva.12228

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